Providing Better Immunology Tools For Better Healthcare ::
Applications
HLA Proteomics
T cell epitope mapping has emerged as one of the most powerful new drug discovery tools for a range of biomedical applications. Initially, T-cell-epitope discovery was applied to the development of vaccines for infectious diseases and cancer. T-cell-epitope-mapping applications have now expanded to include reengineering of protein therapeutics, as well as the fields of autoimmunity, endocrinology, allergy, transplantation and diagnostics. Research employing T-cell-epitope mapping falls within the realm of immunomics, a new field that addresses the interface between host and (pathogen) proteome, bridging genomics, proteomics, immunology and clinical medicine.
A major challenge is the difficulty of finding the right immunogenic element that can achieve an efficient and long-lasting immunization effect. Considerable effort has been made to find suitable fragments (protein epitopes) that can be included in vaccines to offer protection against serious life-threatening diseases. With this growing interest, a clear need for integration of complementary technologies has emerged, aimed at identifying and selecting peptides capable of generating adequate immunomobilization.
Pure Protein has developed a comprehensive, novel antigen-discovery program to detect cancer and viral T-cell epitopes useful in vaccine and therapeutic/diagnostic modalities. A central feature of this program is direct antigen and epitope discovery. Pure Protein's epitope discovery and validation package offers quick and economical means to determine which targets have the greatest potential for a successful vaccine. Pure Protein's suite of technologies is superior to conventional vaccine antigen discovery techniques and our battery of validation tests are unique in their efficacy and economy.
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